Inflammatory Mediators and Modulation of Blood–Brain Barrier Permeability

  title={Inflammatory Mediators and Modulation of Blood–Brain Barrier Permeability},
  author={N. Abbott},
  journal={Cellular and Molecular Neurobiology},
  • N. Abbott
  • Published 2004
  • Medicine, Biology
  • Cellular and Molecular Neurobiology
  • Abstract1. Unlike some interfaces between the blood and the nervous system (e.g., nerve perineurium), the brain endothelium forming the blood–brain barrier can be modulated by a range of inflammatory mediators. The mechanisms underlying this modulation are reviewed, and the implications for therapy of the brain discussed.2. Methods for measuring blood–brain barrier permeability in situ include the use of radiolabeled tracers in parenchymal vessels and measurements of transendothelial resistance… CONTINUE READING
    The blood–brain barrier: an overview: Structure, regulation, and clinical implications
    • 1,559
    • PDF
    The Blood-Brain Barrier/Neurovascular Unit in Health and Disease
    • 1,896
    • PDF
    Astrocyte–endothelial interactions and blood–brain barrier permeability *
    • 93
    Dynamics of CNS Barriers: Evolution, Differentiation, and Modulation
    • 364
    Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier
    • 316
    • PDF


    Publications referenced by this paper.
    Tight Junctions of the Blood–Brain Barrier
    • 308
    Microglia: Intrinsic immuneffector cell of the brain
    • 1,020
    Control of brain endothelial permeability.
    • 117
    • Highly Influential
    Mediators of Blood-Brain Barrier Dysfunction and Formation of Vasogenic Brain Edema
    • 271
    • Highly Influential
    • PDF
    Electrical resistance across the blood‐brain barrier in anaesthetized rats: a developmental study.
    • 606
    Pericyte physiology
    • 366
    Barriers in the Immature Brain
    • 143
    Endothelial Vesicles in the Blood–Brain Barrier: Are They Related to Permeability?
    • 132
    Transporting therapeutics across the blood-brain barrier.
    • 399