Inflammatory Mediators and Insulin Resistance in Obesity: Role of Nuclear Receptor Signaling in Macrophages

@inproceedings{Fuentes2010InflammatoryMA,
  title={Inflammatory Mediators and Insulin Resistance in Obesity: Role of Nuclear Receptor Signaling in Macrophages},
  author={Luc{\'i}a Beatriz Fuentes and Tam{\'a}s Rőszer and Mercedes Ricote},
  booktitle={Mediators of inflammation},
  year={2010}
}
Visceral obesity is coupled to a general low-grade chronic inflammatory state characterized by macrophage activation and inflammatory cytokine production, leading to insulin resistance (IR). The balance between proinflammatory M1 and antiinflammatory M2 macrophage phenotypes within visceral adipose tissue appears to be crucially involved in the development of obesity-associated IR and consequent metabolic abnormalities. The ligand-dependent transcription factors peroxisome proliferator… CONTINUE READING