Inflammatory Gene Regulatory Networks in Amnion Cells Following Cytokine Stimulation: Translational Systems Approach to Modeling Human Parturition

@inproceedings{Li2011InflammatoryGR,
  title={Inflammatory Gene Regulatory Networks in Amnion Cells Following
                    Cytokine Stimulation: Translational Systems Approach to Modeling Human
                    Parturition},
  author={Ruth Li and William Edward Ackerman and Taryn L S Summerfield and Lianbo Yu and Parul Gulati and Jie Zhang and Kun Huang and Roberto Romero and Douglas A. Kniss},
  booktitle={PloS one},
  year={2011}
}
A majority of the studies examining the molecular regulation of human labor have been conducted using single gene approaches. While the technology to produce multi-dimensional datasets is readily available, the means for facile analysis of such data are limited. The objective of this study was to develop a systems approach to infer regulatory mechanisms governing global gene expression in cytokine-challenged cells in vitro, and to apply these methods to predict gene regulatory networks (GRNs… CONTINUE READING
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