Inflammatory Factors Mediate Vulnerability to a Social Stress-Induced Depressive-like Phenotype in Passive Coping Rats

@article{Wood2015InflammatoryFM,
  title={Inflammatory Factors Mediate Vulnerability to a Social Stress-Induced Depressive-like Phenotype in Passive Coping Rats},
  author={Susan K. Wood and Christopher S. Wood and Calliandra M. Lombard and Catherine S. Lee and Rita J Valentino},
  journal={Biological Psychiatry},
  year={2015},
  volume={78},
  pages={38-48}
}
BACKGROUND Coping strategy impacts susceptibility to psychosocial stress. The locus coeruleus (LC) and dorsal raphe (DR) are monoamine nuclei implicated in stress-related disorders. Our goal was to identify genes in these nuclei that distinguish active and passive coping strategies in response to social stress. METHODS Rats were exposed to repeated resident-intruder stress and coping strategy determined. Gene and protein expression in the LC and DR were determined by polymerase chain reaction… CONTINUE READING
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