Inflammatory Cytokines in the Herniated Disc of the Lumbar Spine

  title={Inflammatory Cytokines in the Herniated Disc of the Lumbar Spine},
  author={Hiroshi Takahashi and Toru Suguro and Yukikazu Okazima and Mituo Motegi and Yayoi Okada and Terutaka Kakiuchi},
Study Design Tissues in the area of herniated lumbar discs were examined for inflammatory cytokines to elucidate the causes of sciatic pain in lumbar disc herniation. Objectives To determine the role of inflammatory cytokines in the stimulation of sciatic pain in lumbar disc herniation. Summary of Background Data It is postulated that in addition to mechanical compression of lumbar nerve roots and sensory root ganglia by herniated discs, there is a chemical stimulus to the production of sciatic… 

Macrophage Tissue Infiltration, Clinical Symptoms, and Signs in Patients with Lumbar Disc Herniation. A Clinicopathological Study on 179 Patients

No statistically significant correlation between the histological evidence of macrophage infiltrates in herniated lumbar disc specimen and the obtained clinical data could be found.

mRNA Expression of Cytokines and Chemokines in Herniated Lumbar Intervertebral Discs

Interleukin-8 appears to be associated with development of radicular pain by back extension and to be activated on acute or subacute disc herniations, which implies that it may be considered a target for therapeutic intervention.

The Role of Cyclooxygenase-2 in Lumbar Disc Herniation

Investigation of whether cyclooxygenase-2 might be involved in the pathogenesis of lumbar disc herniation through upregulation of prostaglandin E2 production found that it is possible to downregulate this enzyme in a dose-dependent manner.

Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica

The observation of increased concentrations of IL-8 in CSF in patients with a short duration of symptoms supports the concept of the initial involvement of inflammatory mechanisms after a disc herniation.

Role of interleukin-17 in chondrocytes of herniated intervertebral lumbar discs.

In conclusion, local inflammation and autoreactive immune activation may play an important role in the pathogenesis of LDH and a role of chondrocytes in the repair of herniated IVDs is suggested.

Is There a Clinical Correlate to the Histologic Evidence of Inflammation in Herniated Lumbar Disc Tissue?

Varying amounts of inflammatory cells could be demonstrated in the resected disc tissue, and no statistically significant correlation between the histologic evidence of macrophage infiltrates and the pain grading scale or the clinical data was noted.

Influence of macrophage infiltration of herniated lumbar disc tissue on outcome after lumbar disc surgery.

The results from this study seem to support the theory of a foreign body reaction to the herniated material that may result in inflammation-induced sciatic pain.

Analysis and prevalence of inflammatory cells in subtypes of lumbar disc herniations under cyclooxygenase-2 inhibitor therapy

Although most of the specimens from all the patients showed no significant inflammatory reaction, they all needed surgery with no relief of the symptoms despite conservative therapy, Nerve root compression still seems to be the leading pathomechanism.

Chemokine Profile of Herniated Intervertebral Discs Infiltrated With Monocytes and Macrophages

The findings suggest that chemoattractive properties exist in a selected population of human intervertebral discs, and that unique sets of chemokines play a role in spontaneous regression of these herniated disc tissues.

Cytokine Assay of the Epidural Space Lavage in Patients With Lumbar Intervertebral Disk Herniation and Radiculopathy

Although a novel approach, the current study was unable to identify the presence of a series of inflammatory peptides in the epidural lavage of patients with symptomatic radicular pain due to herniated disc disease.



Chemical radiculitis. A clinical, physiological and immunological study.

Chemical radiculitis is an inflammatory condition of the nerveRoot due to the rupture of the annulus fibrosus and dissemination of disk fluid along the nerve root sheath, which evokes circulating antibody response and auto immune reaction.

The characterization of cytokines in the interface tissue obtained from failed cementless total hip arthroplasty with and without femoral osteolysis.

The histologic, biochemical, and immunohistologic characteristics of the interface membranes surrounding the femoral component of failed cementless total hip arthroplasty in patients with and without radiographic evidence of focal endosteal erosion were studied to suggest that IL-6, IL-1, and TNF play a role in the focal femoral osteolysis observed in Patients with failed cemented hip prostheses.

IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro.

Chondrocytes probably contribute to the increased synovial fluid levels of IL-6 in inflammatory and degenerative conditions of cartilage, and IL- 6 may serve as a mediator to coordinate responses to cartilage injury.

Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis.

This review has summarized some of the evidence suggesting that cytokines may play an important role in mediating pathophysiologic events in RA and further understanding of cytokine inhibitors in the rheumatoid synovium may lead to the development of more specific and effective therapeutic agents.

Prostaglandins, aspirin-like drugs and analgesia.

Compared the pain producing activity of fatty acid hydroperoxides with that of high concentrations of acetylcholine, bradykinin, histamine and PGE1 on intradermal injection in man, the intensity of the pain induced was greater than that induced by the other agonists but for all except P GE1 the pain was transitory.

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts

The ability of cachectin/TNF to stimulate collagenase and PGE2 production suggests that it may play a role in tissue destruction and remodelling, as these processes occur in inflammatory diseases.

The source of low back pain and sciatica.

  • M. Brown
  • Medicine
    Seminars in arthritis and rheumatism
  • 1989

Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients. Possible involvement in joint destruction.

There was a positive correlation between IL-1 production from RA synovium and joint changes detected on roentgenograms, which strongly suggest thatIL-1 might play an important role in the joint destruction in RA.

Induction of human interleukin 1 mRNA measured by collagenase‐ and prostaglandin E2‐stimulating activity in rheumatoid synovial cells

The mRNA of a member of the interleukin 1 family can now be studied in a system based on a specific and direct relevant biological assay and eventually compared with those of other monokines.