Inflammatory Cytokines Released from the Facet Joint Tissue in Degenerative Lumbar Spinal Disorders

@article{Igarashi2004InflammatoryCR,
  title={Inflammatory Cytokines Released from the Facet Joint Tissue in Degenerative Lumbar Spinal Disorders},
  author={Akira Igarashi and Shin‐ichi Kikuchi and Shin-ichi Konno and Kjell Olmarker},
  journal={Spine},
  year={2004},
  volume={29},
  pages={2091-2095}
}
Study Design. A prospective study of surgical cases of degenerative lumbar spinal disorders demonstrated inflammatory cytokines in the facet joint tissue. Objective. To quantify various inflammatory cytokines released from the facet joint tissue in surgical cases of degenerative lumbar spinal disorders. Summary of Background Data. In degenerative lumbar spinal disorders, pain is often caused by osteoarthritis of a facet joint. There are inflammatory mediators such as prostaglandins and… 

Correlation between inflammatory cytokines released from the lumbar facet joint tissue and symptoms in degenerative lumbar spinal disorders

Results suggest the involvement of inflammatory cytokines in degenerated lumbar facet joints regarding the genesis of pain production and a decline of quality of life.

The Effect of Synovial Fluid from Degenerated Facet on Hypertrophy and Ossification of the Ligamentum Flavum

This experimental study cultured human LF cells under the stimulation of synovial fluid from degenerated facet joint and investigated the effect ofsynovial supernatant on cell viability, collagen mRNA expressions and the expressions of osteogenic phenotype and various transcriptional factors on osteogenesis in LF.

Correlation of Tumor Necrosis Factor-α Expression with Pain Level in Degenerative Lumbar Canal Stenosis Patients

TNF-α expression, especially in the facet joint, is significantly associated with the pain intensity and pre-operative ODI that allow pain reduction with less invasive treatment in lumbar canal stenosis patients.

Characterization of degenerative human facet joints and facet joint capsular tissues.

Does Facet Joint Inflammation Induce Radiculopathy?: An Investigation Using a Rat Model of Lumbar Facet Joint Inflammation

When inflammation was induced in a facet joint, inflammatory reactions spread to nerve roots, and leg symptoms were induced by chemical factors, supporting the possibility that facet joint inflammation induces radiculopathy.

A Systematic Review and Best Evidence Synthesis of the Effectiveness of Therapeutic Facet Joint Interventions in Managing Chronic Spinal Pain.

Based on the present assessment for the management of spinal facet joint pain, the evidence for long-term improvement is Level II for lumbar and cervical radiofrequency neurotomy, and therapeutic facet joint nerve blocks in the cervical, thoracic, andlumbar spine.

Facet joint syndrome: from diagnosis to interventional management

The anatomy, epidemiology, clinical presentation, and radiologic findings of facet joint syndrome are described and patients may benefit from specific interventions to eliminate facet joint pain such as neurolysis by radiofrequency or cryoablation.

Pathogenesis, Diagnosis, and Treatment of Lumbar Zygapophysial (Facet) Joint Pain

A comprehensive review of the anatomy, biomechanics, and function of the lumbar zygapophysial joints is provided, along with a systematic analysis of the diagnosis and treatment of facet joint pain.

Facet joint injections for management of low back pain: a clinically focused review

The important aspects of spinal anatomy as they relate to interventional pain management related to facet joint injections are outlined and a comprehensive review of the procedure and clinical evidence is provided.

A New Technique for the Treatment of Lumbar Facet Joint Syndrome Using Intra-articular Injection with Autologous Platelet Rich Plasma.

In the short-term period of 3 months, the new technique of lumbar facet joint injection with autologous PRP is effective and safe for patients with lumbr facet joint syndrome.
...

References

SHOWING 1-10 OF 54 REFERENCES

The lumbar facet arthrosis syndrome. Clinical presentation and articular surface changes.

A lumbar facet syndrome in which disabling symptoms are associated with normal or near-normal plain radiographs is described, and it is suggested that there are both clinical and histological similarities between the facet arthrosis syndrome and chondromalacia patellae.

Prostaglandin Release from Lumbar Disc and Facet Joint Tissue

Because PG release from sequestrated disc is rather low, the inflammatory effect might be more because of immunologic reactions.

LOW BACK PAIN: WITH SPECIAL REFERENCE TO THE ARTICULAR FACETS, WITH PRESENTATION OF AN OPERATIVE PROCEDURE

It has seemed to me that many of the aches and pains which are felt in low back pain are caused by changes around the articular facets which must produce symptoms.

Cytokines and their role in the pathophysiology of osteoarthritis.

This chapter review cytokine interactions and their modulatory effects on joint articular tissue metabolism, including their stimulatory and/or inhibitory actions, and their potential relevance to OA, and the major biological factors that look promising for future therapeutic approaches.

The role of cytokines in osteoarthritis pathophysiology.

The neutralization of IL-1 and/or TNF-alpha up-regulation of MMP gene expression appears to be a logical development in the potential medical therapy of OA, and experimental evidence showing that neutralizing T NF-alpha suppressed cartilage degradation in arthritis also support such strategy.

Cytokines and other mediators in rheumatoid arthritis

This review will specifically focus on the roles of some cellular mediators involved in the different inflammatory phases of rheumatoid arthritis.

Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor α

The elevation of TNFα in inflammation, by virtue of its capacity to induce IL‐1β and NGF, may contribute to the initiation of inflammatory hyperalgesia.

Animal models of arthritis in NOS2-deficient mice.

No plays a major role in cartilage damage in both arthritic and osteoarthritic conditions, and net cartilage proteoglycan depletion was markedly reduced in the absence of NOS2, although inflammation was hardly affected.

Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets.

There is now strong evidence that the structural changes globally observed in OA are due to a combination of factors, ranging from the mechanical to the biochemical, including endogenous factors such as type II collagen mutation or dysplastic conditions.

Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.

It is demonstrated that synoviocyte-derived IL-6 activity was able to induce hybridoma-plasmacytoma proliferation, and immunoglobulin and acute-phase protein synthesis, which can contribute to important manifestations of inflammatory arthropathies.
...