Inflammatory Changes in Bone Marrow Microenvironment Associated with Declining B Lymphopoiesis.

@article{Kennedy2017InflammatoryCI,
  title={Inflammatory Changes in Bone Marrow Microenvironment Associated with Declining B Lymphopoiesis.},
  author={Domenick E Kennedy and Katherine L. Knight},
  journal={Journal of immunology},
  year={2017},
  volume={198 9},
  pages={
          3471-3479
        }
}
B lymphopoiesis arrests precipitously in rabbits such that by 2-4 mo of age, before sexual maturity, little to no B lymphopoiesis occurs in the bone marrow (BM). Previously, we showed that in mice, adipocytes inhibit B lymphopoiesis in vitro by inducing inflammatory myeloid cells, which produce IL-1β. In this study, we characterized rabbit BM after the arrest of B lymphopoiesis and found a dramatic increase in fat, increased CD11b+ myeloid cells, and upregulated expression of the inflammatory… CONTINUE READING
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