Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives

  title={Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives},
  author={Lidia Yshii and Reinhard Hohlfeld and Roland S. Liblau},
  journal={Nature Reviews Neurology},
Cancer treatment strategies based on immune stimulation have recently entered the clinical arena, with unprecedented success. Immune checkpoint inhibitors (ICIs) work by indiscriminately promoting immune responses, which target tumour-associated antigens or tumour-specific mutations. However, the augmented immune response, most notably the T cell response, can cause either direct neurotoxicity or, more commonly, indirect neurotoxic effects through systemic or local inflammatory mechanisms or… 

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