Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives

@article{Yshii2017InflammatoryCD,
  title={Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives},
  author={L. Yshii and R. Hohlfeld and R. Liblau},
  journal={Nature Reviews Neurology},
  year={2017},
  volume={13},
  pages={755-763}
}
Cancer treatment strategies based on immune stimulation have recently entered the clinical arena, with unprecedented success. Immune checkpoint inhibitors (ICIs) work by indiscriminately promoting immune responses, which target tumour-associated antigens or tumour-specific mutations. However, the augmented immune response, most notably the T cell response, can cause either direct neurotoxicity or, more commonly, indirect neurotoxic effects through systemic or local inflammatory mechanisms or… Expand
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