• DOI:10.1038/nrneurol.2017.144
Corpus ID: 41673022

Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives

@article{Yshii2017InflammatoryCD,
  title={Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives},
  author={L. Yshii and R. Hohlfeld and R. Liblau},
  journal={Nature Reviews Neurology},
  year={2017},
  volume={13},
  pages={755-763}
}

• L. Yshii, R. Hohlfeld, R. Liblau
• Published 2017
• Medicine
• Nature Reviews Neurology

Cancer treatment strategies based on immune stimulation have recently entered the clinical arena, with unprecedented success. Immune checkpoint inhibitors (ICIs) work by indiscriminately promoting immune responses, which target tumour-associated antigens or tumour-specific mutations. However, the augmented immune response, most notably the T cell response, can cause either direct neurotoxicity or, more commonly, indirect neurotoxic effects through systemic or local inflammatory mechanisms or… Expand

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