Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives
@article{Yshii2017InflammatoryCD, title={Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives}, author={L. Yshii and R. Hohlfeld and R. Liblau}, journal={Nature Reviews Neurology}, year={2017}, volume={13}, pages={755-763} }
Cancer treatment strategies based on immune stimulation have recently entered the clinical arena, with unprecedented success. Immune checkpoint inhibitors (ICIs) work by indiscriminately promoting immune responses, which target tumour-associated antigens or tumour-specific mutations. However, the augmented immune response, most notably the T cell response, can cause either direct neurotoxicity or, more commonly, indirect neurotoxic effects through systemic or local inflammatory mechanisms or… Expand
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