Inflammatory Biomarkers and Depression

  title={Inflammatory Biomarkers and Depression},
  author={N. Mueller and A. Myint and M. Schwarz},
  journal={Neurotoxicity Research},
  • N. Mueller, A. Myint, M. Schwarz
  • Published 2010
  • Biology, Medicine
  • Neurotoxicity Research
  • Antidepressants, predominantly serotonin- and/or noradrenaline reuptake inhibiting drugs have several shortcomings. The exact pathophysiological mechanisms leading to serotonergic-, noradrenergic- or dopaminergic dysfunction are still unclear. An inflammatory mechanism has been postulated and will be discussed here including possible therapeutic advantages of cyclooxygenase-2 (COX-2) inhibitors. Differences in the activation of the enzyme indoleamine 2,3-dioxygenase (IDO) and in the tryptophan… CONTINUE READING
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