Inflammatory Biomarkers and Depression

@article{Mller2010InflammatoryBA,
  title={Inflammatory Biomarkers and Depression},
  author={N. M{\"u}ller and A. Myint and M. Schwarz},
  journal={Neurotoxicity Research},
  year={2010},
  volume={19},
  pages={308-318}
}
Antidepressants, predominantly serotonin- and/or noradrenaline reuptake inhibiting drugs have several shortcomings. The exact pathophysiological mechanisms leading to serotonergic-, noradrenergic- or dopaminergic dysfunction are still unclear. An inflammatory mechanism has been postulated and will be discussed here including possible therapeutic advantages of cyclooxygenase-2 (COX-2) inhibitors. Differences in the activation of the enzyme indoleamine 2,3-dioxygenase (IDO) and in the tryptophan… Expand
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