Inflammation regulates functional integration of neurons born in adult brain.

  title={Inflammation regulates functional integration of neurons born in adult brain.},
  author={Katherine Jakubs and S. V. Bonde and Robert E Iosif and Christine T. Ekdahl and Zaal Kokaia and Merab Kokaia and Olle Lindvall},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={28 47},
Inflammation influences several steps of adult neurogenesis, but whether it regulates the functional integration of the new neurons is unknown. Here, we explored, using confocal microscopy and whole-cell patch-clamp recordings, whether a chronic inflammatory environment affects the morphological and electrophysiological properties of new dentate gyrus granule cells, labeled with a retroviral vector encoding green fluorescent protein. Rats were exposed to intrahippocampal injection of… CONTINUE READING


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