Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

@inproceedings{Mowers2013InflammationPC,
  title={Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1},
  author={Jonathan C Mowers and Maeran Uhm and Shannon M. Reilly and Joshua S. Simon and Dara Leto and Shian-Huey Chiang and Louise Chang and Alan R. Saltiel},
  booktitle={eLife},
  year={2013}
}
Obesity produces a chronic inflammatory state involving the NFκB pathway, resulting in persistent elevation of the noncanonical IκB kinases IKKε and TBK1. In this study, we report that these kinases attenuate β-adrenergic signaling in white adipose tissue. Treatment of 3T3-L1 adipocytes with specific inhibitors of these kinases restored β-adrenergic signaling and lipolysis attenuated by TNFα and Poly (I:C). Conversely, overexpression of the kinases reduced induction of Ucp1, lipolysis, cAMP… CONTINUE READING

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