Inflammation occurs early during the Abeta deposition process in TgCRND8 mice.

@article{Dudal2004InflammationOE,
  title={Inflammation occurs early during the Abeta deposition process in TgCRND8 mice.},
  author={Sherri Dudal and Pascale Krzywkowski and Julie Paquette and C{\'e}line Morissette and Diane Lacombe and Patrick Tremblay and Francine Gervais},
  journal={Neurobiology of aging},
  year={2004},
  volume={25 7},
  pages={861-71}
}
Alzheimer's disease (AD) is characterized by a progressive cognitive decline leading to dementia and involves the deposition of amyloid-beta (Abeta) peptides into senile plaques. Other neuropathological features that accompany progression of the disease include a decrease in synaptic density, neurofibrillary tangles, dystrophic neurites, inflammation, and neuronal cell loss. In this study, we report the early kinetics of brain amyloid deposition and its associated inflammation in an early onset… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

Similar Papers

Loading similar papers…