Inflammation is detrimental for neurogenesis in adult brain.

  title={Inflammation is detrimental for neurogenesis in adult brain.},
  author={Christine T. Ekdahl and J Claasen and S. V. Bonde and Zaal Kokaia and Olle Lindvall},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 23},
New hippocampal neurons are continuously generated in the adult brain. Here, we demonstrate that lipopolysaccharide-induced inflammation, which gives rise to microglia activation in the area where the new neurons are born, strongly impairs basal hippocampal neurogenesis in rats. The increased neurogenesis triggered by a brain insult is also attenuated if it is associated with microglia activation caused by tissue damage or lipopolysaccharide infusion. The impaired neurogenesis in inflammation… CONTINUE READING
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