Inflammation is associated with a reduced number of pro-angiogenic Tie-2 monocytes and endothelial progenitor cells in patients with critical limb ischemia

@article{Dopheide2015InflammationIA,
  title={Inflammation is associated with a reduced number of pro-angiogenic Tie-2 monocytes and endothelial progenitor cells in patients with critical limb ischemia},
  author={J{\"o}rn F Dopheide and Philipp Geissler and Jennifer Rubrech and Amelie Trumpp and Geraldine C. Zeller and Karsten Bock and Bernhard Dorweiler and Friedrich Duenschede and Thomas F. M{\"u}nzel and Markus P Radsak and Christine Espinola-Klein},
  journal={Angiogenesis},
  year={2015},
  volume={19},
  pages={67-78}
}
Inflammation is the driving force in atherosclerosis. One central strategy in the treatment for PAD is the promotion of angiogenesis. Here, pro-angiogenic Tie-2-expressing monocytes (TEM) and endothelial progenitor cells (EPC) play a crucial role. Critical limb ischemia (CLI) is characterized by a severe, chronic inflammatory response; thus, progression of the disease might be related to the deleterious effects of inflammation on pro-angiogenic cells. Forty-five patients with intermittent… CONTINUE READING
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