Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation.


The tumor suppressor programmed cell death 4 (Pdcd4) is lost in various tumor tissues. Loss of Pdcd4 has been associated with increased tumorigenic potential and tumor progression. While various mechanisms of Pdcd4 regulation have been described, the effect of an inflammatory tumor microenvironment on Pdcd4 protein expression has not been characterized so… (More)
DOI: 10.1093/carcin/bgr131


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@article{Schmid2011InflammationinducedLO, title={Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation.}, author={Tobias Schmid and Magdalena M. Bajer and Johanna S. Blees and Lisa K Eifler and Larissa Milke and Daniela R{\"{u}bsamen and Kathrin Schulz and Andreas Weigert and Alyson R. Baker and Nancy H. Colburn and Bernhard Br{\"{u}ne}, journal={Carcinogenesis}, year={2011}, volume={32 10}, pages={1427-33} }