Inflammation-induced lethargy is mediated by suppression of orexin neuron activity.

@article{Grossberg2011InflammationinducedLI,
  title={Inflammation-induced lethargy is mediated by suppression of orexin neuron activity.},
  author={Aaron J Grossberg and Xinxia Zhu and Gina M Leinninger and Peter R. Levasseur and Theodore P. Braun and Martin G Myers and Daniel L Marks},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 31},
  pages={11376-86}
}
In response to illness, animals subvert normal homeostasis and divert their energy utilization to fight infection. An important and unexplored feature of this response is the suppression of physical activity and foraging behavior in the setting of negative energy balance. Inflammatory signaling in the hypothalamus mediates the febrile and anorectic responses to disease, but the mechanism by which locomotor activity (LMA) is suppressed has not been described. Lateral hypothalamic orexin (Ox… CONTINUE READING
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