Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress.

@article{Clapp2004InflammationinducedED,
  title={Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress.},
  author={Brian Clapp and Aroon D. Hingorani and Rajesh K. Kharbanda and Vidya Mohamed-Ali and Jeffrey W Stephens and Patrick J. T. Vallance and Raymond J Macallister},
  journal={Cardiovascular research},
  year={2004},
  volume={64 1},
  pages={172-8}
}
OBJECTIVES Our aim was to investigate mechanisms of inflammation-induced endothelial dysfunction in humans. METHODS Endothelial function in twenty-one healthy human volunteers was measured using forearm venous plethysmography before and 8 h after administration of typhoid vaccination to generate an inflammatory response. Basal and stimulated endothelial nitric oxide (NO) bioavailability was assessed by measurement of the responses to intra-arterial N(G)-monomethyl-l-arginine (l-NMMA) and… CONTINUE READING

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