Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy

@article{Shi2019InflammationIB,
  title={Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy},
  author={Liangrong Shi and Junjun Wang and Nianhua Ding and Yi Zhang and Yi-bei Zhu and Shunli Dong and Xiaohui Wang and Changli Peng and Chunhui Zhou and Ledu Zhou and Xiaodong Li and Hong-bing Shi and Wei Wu and Xue-Ying Long and Changping Wu and Weihua Liao},
  journal={Nature Communications},
  year={2019},
  volume={10}
}
Radiofrequency ablation (RFA) promotes tumor antigen-specific T cell responses and enhances the effect of immunotherapy in preclinical settings. Here we report that the existence of remnant tumor masses due to incomplete RFA (iRFA) is associated with earlier new metastases and poor survival in patients with colorectal cancer liver metastases (CRCLM). Using mouse models, we demonstrate that iRFA promotes tumor progression and hinders the efficacy of anti-PD-1 therapy. Immune analysis reveals… 
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