Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

  title={Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.},
  author={Sandra Baumgart and Na Chen and Jens T. Siveke and A. Koenig and Jin-San Zhang and Shiv K. Singh and Elmar Wolf and Marek Bartkuhn and Irene Esposito and Elisabeth Hessmann and Johanna Reinecke and Julius Nikorowitsch and Marius Brunner and Garima R. Singh and Martin E Fernandez-Zapico and Thomas T Smyrk and William R. Bamlet and Martin Eilers and Albrecht Neesse and Thomas Matthias Gress and Daniel D Billadeau and David A Tuveson and Raul A Urrutia and Volker Ellenrieder},
  journal={Cancer discovery},
  volume={4 6},
UNLABELLED Cancer-associated inflammation is a molecular key feature in pancreatic ductal adenocarcinoma. Oncogenic KRAS in conjunction with persistent inflammation is known to accelerate carcinogenesis, although the underlying mechanisms remain poorly understood. Here, we outline a novel pathway whereby the transcription factors NFATc1 and STAT3 cooperate in pancreatic epithelial cells to promote Kras(G12D)-driven carcinogenesis. NFATc1 activation is induced by inflammation and itself… CONTINUE READING
Highly Cited
This paper has 48 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 32 extracted citations

GSK-3β Governs Inflammation-Induced NFATc2 Signaling Hubs to Promote Pancreatic Cancer Progression.

Molecular cancer therapeutics • 2016
View 4 Excerpts
Method Support
Highly Influenced

Role of the EZH2/miR-200 axis in STAT3-mediated OSCC invasion

International journal of oncology • 2018
View 1 Excerpt