Inflammation increases sufentanil requirements during surgery for inflammatory bowel diseases.

@article{Guidat2003InflammationIS,
  title={Inflammation increases sufentanil requirements during surgery for inflammatory bowel diseases.},
  author={Anne Guidat and Maher Fleyfel and Beno{\^i}t Vallet and Pierre Desreumaux and J. C. Levron and Luc Gambiez and Jean Fr{\'e}d{\'e}ric Colombel and Philippe Scherpereel},
  journal={European journal of anaesthesiology},
  year={2003},
  volume={20 12},
  pages={957-62}
}
BACKGROUND AND OBJECTIVE Inflammation promotes hyperalgesia and increases opioid binding protein (alpha1-acid glycoprotein) inducing increased opioid requirement. To investigate the influence of an acute episode of inflammatory bowel disease in opioid requirement during major abdominal surgery, 17 patients with Crohn's disease, 12 patients with ulcerative colitis and seven patients without any inflammatory process (control group) were prospectively studied. Sufentanil requirements were assessed… CONTINUE READING