Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion.

@article{Festa2003InflammationIT,
  title={Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion.},
  author={Andreas Festa and Anthony J. G. Hanley and Russell P Tracy and Ralph D D'Agostino and Steven M. Haffner},
  journal={Circulation},
  year={2003},
  volume={108 15},
  pages={1822-30}
}
BACKGROUND Elevated levels of proinflammatory proteins are predictive of both cardiovascular (CV) disease and type 2 diabetes. Previously, atherogenic changes in traditional CV risk factors in the prediabetic state were mainly seen in insulin-resistant subjects rather than in those with a predominant defect in insulin secretion. METHODS AND RESULTS We studied in prediabetic individuals from the Insulin Resistance Atherosclerosis Study (IRAS) the relation of C-reactive protein (CRP… CONTINUE READING
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Elevated levels of acute phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the Insulin Resistance Atherosclerosis Study

  • A Festa, R JrD’Agostino, RP Tracy
  • 2002

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