Inflammation in the intestinal tract: pathogenesis and treatment.

  title={Inflammation in the intestinal tract: pathogenesis and treatment.},
  author={Richard S Blumberg},
  journal={Digestive diseases},
  volume={27 4},
Over the past decade a major hypothesis has emerged for the etiopathogenesis of inflammatory bowel disease (IBD). This hypothesis proposes that IBD represents a dysregulated mucosal immune response to antigens derived from the commensal microbiota in a genetically susceptible host that initially derives from innate immune abnormalities leading to an excessive proinflammatory cytokine derived from CD4+ T cells (T-helper 1, T-helper 2, and T-helper 17 cytokines) over and above the response that… CONTINUE READING


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