Inflammation in the genesis and perpetuation of atrial fibrillation.

@article{Engelmann2005InflammationIT,
  title={Inflammation in the genesis and perpetuation of atrial fibrillation.},
  author={Mads D.M. Engelmann and Jesper Hastrup Svendsen},
  journal={European heart journal},
  year={2005},
  volume={26 20},
  pages={
          2083-92
        }
}
The prevalence and persistence of atrial fibrillation (AF) and the relative inefficacy of the currently available pharmacotherapy requires development of new treatment strategies. Recent findings have suggested a mechanistic link between inflammatory processes and the development of AF. Epidemiological studies have shown an association between C-reactive protein and both the presence of AF and the risk of developing future AF. In case-control studies, C-reactive protein is significantly… 
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Update on the Association of Inflammation and Atrial Fibrillation
TLDR
The purpose of this review is to provide current evidence on the relationship between inflammation and AF and potential therapies available to modulate the inflammatory state in AF.
Role of inflammation in initiation and perpetuation of atrial fibrillation: a systematic review of the published data.
The Emerging Role of Inflammation and Fibrosis in Atrial Fibrillation and the Potential of Counter Interventions
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Data from five comparative studies of a primary rate control vs. rhythm control strategy for patients with a history of AF failed to show a significant superiority of rhythm control, highlighting the limited efficacy and high side-effect profile of the currently available anti-arrhythmic drugs.
Pleiotropic effects of statins in atrial fibrillation patients: the evidence
TLDR
Despite a growing body of evidence that drugs with anti-inflammatory properties such as statins may prevent AF, the observed positive effects of statins on the burden of AF appeared to be independent of their cholesterol-reducing properties.
Is atrial fibrillation an inflammatory disorder?
TLDR
An overview of the evidence supporting a link between inflammation and AF, and some of the drug therapies that might be efficacious in the prevention of AF by modulating inflammatory pathways are presented.
Is atrial fibrillation an inflammatory disease?
Inflammatory markers in paroxysmal atrial fibrillation and the protective role of renin-angiotensin-aldosterone system inhibitors
TLDR
Inflammation is present in patients with AF, with or without treatment with RAAS inhibitors and is correlated with longer duration of AF, left atrial diameter andleft atrial volume.
Interleukin-18 among atrial fibrillation patients in the absence of structural heart disease.
  • Ying Luan, Yuanyuan Guo, +10 authors Ye Tian
  • Medicine, Biology
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
  • 2010
TLDR
Interleukin-18 may be superior to other inflammatory markers which are known to be elevated in atrial fibrillation patients, and this study documents the elevated IL-18 in AF patients.
The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation.
C-Reactive Protein and Atrial Fibrillation. An Old Marker Looking for of a New Target
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