Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance.

@article{Steinberg2007InflammationIO,
  title={Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance.},
  author={Gregory R Steinberg},
  journal={Cell cycle},
  year={2007},
  volume={6 8},
  pages={888-94}
}
Over the past two decades increases in obesity, due to high caloric intakes and immobilizing technologies, has led to a surge in type 2 diabetes. In obesity elevated circulating fatty acids set-off a pro-inflammatory cascade that increases the production of tumour necrosis factor-alpha(TNFalpha) from macrophages. Obesity is associated with blunted skeletal muscle fatty acid oxidation, accumulation of bioactive lipids and insulin resistance. The factors contributing to defects in fatty acid… CONTINUE READING

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