Inflammation in atherosclerosis

  title={Inflammation in atherosclerosis},
  author={Peter Libby},
  • P. Libby
  • Published 19 December 2002
  • Biology
  • Nature
Abundant data link hypercholesterolaemia to atherogenesis. However, only recently have we appreciated that inflammatory mechanisms couple dyslipidaemia to atheroma formation. Leukocyte recruitment and expression of pro-inflammatory cytokines characterize early atherogenesis, and malfunction of inflammatory mediators mutes atheroma formation in mice. Moreover, inflammatory pathways promote thrombosis, a late and dreaded complication of atherosclerosis responsible for myocardial infarctions and… 

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