Inflammation in atherosclerosis

@article{Libby2002InflammationIA,
  title={Inflammation in atherosclerosis},
  author={P. Libby},
  journal={Nature},
  year={2002},
  volume={420},
  pages={868-874}
}
Abundant data link hypercholesterolaemia to atherogenesis. However, only recently have we appreciated that inflammatory mechanisms couple dyslipidaemia to atheroma formation. Leukocyte recruitment and expression of pro-inflammatory cytokines characterize early atherogenesis, and malfunction of inflammatory mediators mutes atheroma formation in mice. Moreover, inflammatory pathways promote thrombosis, a late and dreaded complication of atherosclerosis responsible for myocardial infarctions and… Expand

Paper Mentions

Observational Clinical Trial
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ConditionsCardiovascular Disease, Diabetes Mellitus, Healthy Volunteer, (+1 more)
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InterventionDevice
Interventional Clinical Trial
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ConditionsAtherosclerosis
InterventionBehavioral, Drug
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References

SHOWING 1-10 OF 124 REFERENCES
Inflammation and Atherosclerosis
TLDR
New insights into inflammation in atherosclerosis not only increase the understanding of this disease, but also have practical clinical applications in risk stratification and targeting of therapy for this scourge of growing worldwide importance. Expand
Hyperlipidemia and atherosclerosis.
TLDR
The present studies indicate that the effects of chronic hyperlipidemia are complex in that the condition results not only in the deposition of lipids in the atheromatous lesions but that it may produce the primary endothelial injury that initiates the process of atherosclerosis as well. Expand
NF-κB: pivotal mediator or innocent bystander in atherogenesis?
TLDR
One transcription factor, NF-κB, whose activation has been linked to the onset of atherosclerosis is focused on, which activates a variety of target genes relevant to the pathophysiology of the vessel wall, as well as genes that regulate cell proliferation and mediate cell survival. Expand
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
TLDR
A role for IL-6 is proposed in the pathogenesis of CHD through a combination of autocrine, paracrine and endocrine mechanisms, activation of which is associated with central obesity, hypertension and insulin resistance. Expand
Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis
TLDR
A role for MCP-1 in the development of early atherosclerotic lesions is revealed and upregulation of this chemokine by minimally oxidized lipids is an important link between hyperlipidaemia and fatty streak formation. Expand
The unstable atheroma.
TLDR
It is proposed that the basic biology of the unstable lesion will now assume even greater importance for two fundamental reasons: first, even with aspirin and cholesterol-lowering therapy, acute vascular events will continue to be a major cause of morbidity and mortality in developed countries. Expand
Cytokines as mediators of vascular pathology.
TLDR
The laboratory has been interested in hyperplastic arterial diseases including atherosclerosis and restenosis following angioplasty treatment of obstructive Atherosclerosis, and Definitive evidence for roles of cytokines in the pathogenesis of these syndromes are lacking, but various in vitro and in vivo studies have furnished sufficient information to permit formulation of rather detailed hypotheses or models. Expand
Pathogenesis of atherosclerosis.
  • S. Moore
  • Biology, Medicine
  • Metabolism: clinical and experimental
  • 1985
TLDR
Modifications of the thrombotic process, such as increasedproduction of thromboxane by platelets, decreased production of prostacyclin by the endothelium, and increased production of von Willebrand factor further enhance the throttle and may be important in the initiation and subsequent progression of atherosclerosis in diabetics. Expand
Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis
Abstract— This review considers critically the evidence for the involvement of mediators of innate and acquired immunity in various stages of atherosclerosis. Rapidly mobilized arms of innateExpand
Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model.
TLDR
Using a transgenic approach, the mutual perpetuation of immune-mediated arterial inflammation and hypercholesterolemia favors initiation and maintenance of atherosclerotic lesion formation is described. Expand
...
1
2
3
4
5
...