Inflammation in atherosclerosis

@article{Libby2002InflammationIA,
  title={Inflammation in atherosclerosis},
  author={Peter Libby},
  journal={Nature},
  year={2002},
  volume={420},
  pages={868-874}
}
  • P. Libby
  • Published 19 December 2002
  • Biology
  • Nature
Abundant data link hypercholesterolaemia to atherogenesis. However, only recently have we appreciated that inflammatory mechanisms couple dyslipidaemia to atheroma formation. Leukocyte recruitment and expression of pro-inflammatory cytokines characterize early atherogenesis, and malfunction of inflammatory mediators mutes atheroma formation in mice. Moreover, inflammatory pathways promote thrombosis, a late and dreaded complication of atherosclerosis responsible for myocardial infarctions and… 

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References

SHOWING 1-10 OF 110 REFERENCES

Inflammation and Atherosclerosis

TLDR
New insights into inflammation in atherosclerosis not only increase the understanding of this disease, but also have practical clinical applications in risk stratification and targeting of therapy for this scourge of growing worldwide importance.

NF-κB: pivotal mediator or innocent bystander in atherogenesis?

TLDR
One transcription factor, NF-κB, whose activation has been linked to the onset of atherosclerosis is focused on, which activates a variety of target genes relevant to the pathophysiology of the vessel wall, as well as genes that regulate cell proliferation and mediate cell survival.

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

TLDR
A role for MCP-1 in the development of early atherosclerotic lesions is revealed and upregulation of this chemokine by minimally oxidized lipids is an important link between hyperlipidaemia and fatty streak formation.

The unstable atheroma.

  • R. LeeP. Libby
  • Medicine
    Arteriosclerosis, thrombosis, and vascular biology
  • 1997
TLDR
It is proposed that the basic biology of the unstable lesion will now assume even greater importance for two fundamental reasons: first, even with aspirin and cholesterol-lowering therapy, acute vascular events will continue to be a major cause of morbidity and mortality in developed countries.

Cytokines as mediators of vascular pathology.

TLDR
The laboratory has been interested in hyperplastic arterial diseases including atherosclerosis and restenosis following angioplasty treatment of obstructive Atherosclerosis, and Definitive evidence for roles of cytokines in the pathogenesis of these syndromes are lacking, but various in vitro and in vivo studies have furnished sufficient information to permit formulation of rather detailed hypotheses or models.

Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis

Abstract— This review considers critically the evidence for the involvement of mediators of innate and acquired immunity in various stages of atherosclerosis. Rapidly mobilized arms of innate

Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model.

TLDR
Using a transgenic approach, the mutual perpetuation of immune-mediated arterial inflammation and hypercholesterolemia favors initiation and maintenance of atherosclerotic lesion formation is described.

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.

TLDR
It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.

Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis.

TLDR
In dietary hypercholesterolemic and Watanabe heritable hyperlipidemic rabbit models of atherosclerosis, this inducible rabbit endothelial adhesion molecule was found to be expressed in a localized fashion by aortic endothelium that overlies early foam cell lesions, suggesting a potential endothelia-dependent mechanism for mononuclear leukocyte recruitment during atherogenesis.
...