Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells.

@article{Graves2004InflammationIA,
  title={Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells.},
  author={Michael C. Graves and Milan Fiala and Lu Anne Velayo Dinglasan and Nancy Liu and James Sayre and Francesco Chiappelli and Cees van Kooten and H V Vinters},
  journal={Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases},
  year={2004},
  volume={5 4},
  pages={213-9}
}
Recent studies have shown inflammatory markers in affected neural tissues of amyotrophic lateral sclerosis (ALS) patients. We examined immunocytochemically spinal cord tissues of six patients with ALS, two with corticospinal tract degeneration secondary to cerebral infarcts and three control subjects without neuropathologic abnormalities. ALS spinal cords had dense macrophage infiltration (one log greater than control spinal cords) involving the white and gray matter, with heaviest infiltration… CONTINUE READING