Inflammation imaging by silica nanoparticles with antibodies orientedly immobilized.

@article{Shirai2012InflammationIB,
  title={Inflammation imaging by silica nanoparticles with antibodies orientedly immobilized.},
  author={Tomoaki Shirai and Hiroshi Kohara and Yasuhiko Tabata},
  journal={Journal of drug targeting},
  year={2012},
  volume={20 6},
  pages={535-43}
}
The objective of this study is to design fluorescent nanoprobes for inflammation imaging. An antibody against CD11b expressed on the surfaces of mouse macrophages (anti-CD11b), was fluorescently labeled. Protein G, which has an ability to bind the Fc region of antibody, was conjugated onto the surface of silica nanoparticles (SiNP). Then, the fluorescent… CONTINUE READING