Inflammation elevated IL-33 originating from the lung mediates inflammation in acute lung injury.

@article{Lin2016InflammationEI,
  title={Inflammation elevated IL-33 originating from the lung mediates inflammation in acute lung injury.},
  author={Shi-hui Lin and Juan Fu and Chuan-jiang Wang and Feng Gao and Xuan-Yun Feng and Qiong Liu and Ju Jiang Cao and Fang Xu},
  journal={Clinical immunology},
  year={2016}
}
Excessive inflammatory reactions occur with acute respiratory distress syndrome (ARDS), however, the underlying mechanisms of ARDS remain incompletely understood. Here we investigated whether interleukin (IL)-33 was elevated in ARDS patients. Serum samples were obtained from 14 ARDS patients and 24 control healthy volunteers. ELISA was used to measure the concentrations of IL-33. Besides, we established pulmonary ARDS and extrapulmonary ARDS models in mice, and serum and lung tissue samples… CONTINUE READING