Inflammation causes a long-term hyperexcitability in the nociceptive sensory neurons of Aplysia.

@article{Farr1999InflammationCA,
  title={Inflammation causes a long-term hyperexcitability in the nociceptive sensory neurons of Aplysia.},
  author={Mary Jane Farr and Jay Mathews and D F Zhu and Richard Ambron},
  journal={Learning & memory},
  year={1999},
  volume={6 3},
  pages={331-40}
}
Nerve injury, tissue damage, and inflammation all cause hyperalgesia. A factor contributing to this increased sensitivity is a long-term (>24 hr) hyperexcitability (LTH) in the sensory neurons that mediate the responses. Using the cluster of nociceptive sensory neurons in Aplysia californica as a model, we are examining how inflammation induces LTH. A general inflammatory response was induced by inserting a gauze pad into the animal Within 4 days, the gauze is enmeshed in an amorphous material… CONTINUE READING
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