Inflammation boosts bacteriophage transfer between Salmonella spp.

  title={Inflammation boosts bacteriophage transfer between Salmonella spp.},
  author={M{\'e}d{\'e}ric Diard and Erik Bakkeren and Jeffrey K Cornuault and Kathrin Moor and Annika Hausmann and Mikael Erik Sellin and Claude Loverdo and Abram Aertsen and Martin Ackermann and Marianne De Paepe and Emma Slack and Wolf-Dietrich Hardt},
Bacteriophage transfer (lysogenic conversion) promotes bacterial virulence evolution. There is limited understanding of the factors that determine lysogenic conversion dynamics within infected hosts. A murine Salmonella Typhimurium (S.Tm) diarrhea model was used to study the transfer of SopEΦ, a prophage from S.Tm SL1344, to S.Tm ATCC14028S. Gut inflammation and enteric disease triggered >55% lysogenic conversion of ATCC14028S within 3 days. Without inflammation, SopEΦ transfer was reduced by… CONTINUE READING