Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer.

@article{Chang2008InflammationassociatedLA,
  title={Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer.},
  author={David H. Chang and Haiteng Deng and Phillip M. Matthews and Joseph Krasovsky and Govind Ragupathi and Radek {\vS}p{\'i}{\vs}ek and Amitabha Mazumder and David H Vesole and Sundar Jagannath and Madhav V Dhodapkar},
  journal={Blood},
  year={2008},
  volume={112 4},
  pages={
          1308-16
        }
}
CD1d-restricted T cells have been implicated in the pathogenesis of several chronic inflammatory states. However, the nature of the specific ligands recognized by these cells in vivo in patients with inflammatory or malignant diseases remains unknown. We took a biochemical approach to directly isolate and characterize the nature of CD1d-binding ligands from the plasma of myeloma patients. Characterization of these ligands revealed several lysophosphatidylcholine (LPC) species. Human LPC-CD1d… CONTINUE READING

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