Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation.

@article{Chiba2012InflammationassociatedCD,
  title={Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation.},
  author={Tsutomu Chiba and Hiroyuki Marusawa and Toshikazu Ushijima},
  journal={Gastroenterology},
  year={2012},
  volume={143 3},
  pages={
          550-563
        }
}
Chronic inflammation, regardless of infectious agents, plays important roles in the development of various cancers, particularly in digestive organs, including Helicobacter pylori-associated gastric cancer, hepatitis C virus-positive hepatocellular carcinoma, and colitis-associated colon cancers. Cancer development is characterized by stepwise accumulation of genetic and epigenetic alterations of various proto-oncogenes and tumor-suppressor genes. During chronic inflammation, infectious agents… 

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