Inflammation as a central mechanism in Alzheimer's disease

@inproceedings{Kinney2018InflammationAA,
  title={Inflammation as a central mechanism in Alzheimer's disease},
  author={Jefferson W. Kinney and Shane M. Bemiller and Andrew Scott Murtishaw and Amanda M. Leisgang and Arnold M. Salazar and Bruce T Lamb},
  booktitle={Alzheimer's & dementia},
  year={2018}
}
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by cognitive decline and the presence of two core pathologies, amyloid β plaques and neurofibrillary tangles. Over the last decade, the presence of a sustained immune response in the brain has emerged as a third core pathology in AD. The sustained activation of the brain's resident macrophages (microglia) and other immune cells has been demonstrated to exacerbate both amyloid and tau pathology and may… CONTINUE READING

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Beneficial effects of curtailing immune susceptibility in an Alzheimer’s disease model

Giulia Di Benedetto, Chiara Burgaletto, +6 authors Giuseppina Cantarella
  • Journal of Neuroinflammation
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