Inflammation and the pathogenesis of diabetic nephropathy.

  title={Inflammation and the pathogenesis of diabetic nephropathy.},
  author={Jun Wada and Hirofumi Makino},
  journal={Clinical science},
  volume={124 3},
The most problematic issue in clinical nephrology is the relentless and progressive increase in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic nephropathy on the increasing population with CKD (chronic kidney disease) and ESRD is enormous. Three major pathways showing abnormality of intracellular metabolism have been identified in the development of diabetic nephropathy: (i) the activation of polyol and PKC (protein kinase C) pathways; (ii) the formation of… CONTINUE READING