Inflammation and portal hypertension - the undiscovered country.

  title={Inflammation and portal hypertension - the undiscovered country.},
  author={Gautam Mehta and Thierry Gustot and Rajeshwar P Mookerjee and Juan Carlos Garc{\'i}a-Pag{\'a}n and Michael Brooks Fallon and Vijay H Shah and Richard Moreau and Rajiv Jalan},
  journal={Journal of hepatology},
  volume={61 1},
Portal hypertension has traditionally been viewed as a progressive process, involving ultrastructural changes including fibrosis, nodule formation, and vascular thrombosis, leading to increased intrahepatic resistance to flow. However, it is increasingly recognized that a significant component of this vascular resistance results from a dynamic process, regulated by complex interactions between the injured hepatocyte, the sinusoidal endothelial cell, the Kupffer cell and the hepatic stellate… CONTINUE READING