Inflammation and polyamine catabolism: the good, the bad and the ugly.

  title={Inflammation and polyamine catabolism: the good, the bad and the ugly.},
  author={Naveen Babbar and Tracey Murray-Stewart and Robert Anthony Casero},
  journal={Biochemical Society transactions},
  volume={35 Pt 2},
The induction of polyamine catabolism by specific anti-tumour polyamine analogues has increased interest in the roles polyamine catabolism play in cell growth, death and response to various anti-tumour agents. The relatively recent finding of an inducible mammalian spermine oxidase (SMO/PAOh1), in addition to the two-step spermidine/spermine N(1)-acetyltransferanse (SSAT)/N(1)-acetylpolyamine oxidase (APAO) catabolic pathway, underscores the complexities of the regulation of polyamine… CONTINUE READING


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