Inflammation and necrosis promote tumour growth

  title={Inflammation and necrosis promote tumour growth},
  author={Jukka M Vakkila and Michael T Lotze},
  journal={Nature Reviews Immunology},
In children, cancer probably arises from a combination of inherited genetic mutations and genetic alterations that are acquired during the rapid cellular expansion that occurs during embryogenesis, and it is rarely associated with immune cell infiltrates. Conversely, in adults, cancer is frequently preceded by a long period of subclinical inflammatory disease and micronecrosis that provides a setting in which the epigenetic regulation of genes, cell death, cell proliferation and mutagenesis… CONTINUE READING
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