Inflammation and its genesis in cystic fibrosis.

@article{Nichols2015InflammationAI,
  title={Inflammation and its genesis in cystic fibrosis.},
  author={David P Nichols and James F Chmiel},
  journal={Pediatric pulmonology},
  year={2015},
  volume={50 Suppl 40},
  pages={S39-56}
}
The host inflammatory response in cystic fibrosis (CF) lung disease has long been recognized as a central pathological feature and an important therapeutic target. Indeed, many believe that bronchiectasis results largely from the oxidative and proteolytic damage comprised within an exuberant airway inflammatory response that is dominated by neutrophils. In this review, we address the longstanding argument of whether or not the inflammatory response is directly attributable to impairment of the… CONTINUE READING
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The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis

  • KA Becker, J Riethm€uller, Y Zhang, E. Gulbins
  • Open Respir Med J 2010;4:39–47
  • 2010
Highly Influential
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