Inflammation and intestinal metaplasia of the gastric cardia: the role of gastroesophageal reflux and H. pylori infection.

@article{Goldblum1998InflammationAI,
  title={Inflammation and intestinal metaplasia of the gastric cardia: the role of gastroesophageal reflux and H. pylori infection.},
  author={J. Goldblum and J. Vicari and G. Falk and T. Rice and R. Peek and Kirk A Easley and J. Richter},
  journal={Gastroenterology},
  year={1998},
  volume={114 4},
  pages={
          633-9
        }
}
BACKGROUND & AIMS Whether inflammation of the cardia indicates gastroesophageal reflux disease (GERD) and/or is a manifestation of pangastritis caused by Helicobacter pylori infection is unknown. The aim of this study was to evaluate the relationship between cardia inflammation, H. pylori infection, and cardia intestinal metaplasia in patients with and without GERD. METHODS Patients with GERD were compared with controls undergoing endoscopy for a variety of other conditions. Endoscopic biopsy… Expand
Helicobacter pylori infection, not gastroesophageal reflux, is the major cause of inflammation and intestinal metaplasia of gastric cardiac mucosa
TLDR
Inflammation of gastric cardiac mucosa decreases in prevalence from controls to patients with GERD and Barrett's esophagus and correlates strongly with H. pylori-related cardiac inflammation and intestinal metaplasia elsewhere in the stomach. Expand
Gastric cardia inflammation: role of helicobacter pylori infection and symptoms of gastroesophageal reflux disease
TLDR
According to the study data, the gastric cardia is frequently infected with H. pylori with consequent development of both carditis and intestinal metaplasia, whereas GERD does not seem to be involved in these histological changes. Expand
Relationship between intestinal metaplasia of the gastro-oesophageal junction, Helicobacter pylori infection and gastro-oesophageal reflux disease: a prospective study.
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  • Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2000
TLDR
Inflammation and intestinal metaplasia of the gastric cardia are not markers of gastro-oesophageal reflux disease but are related to Helicobacter pylori. Expand
Intestinal Metaplasia of Gastric Cardia and Carditis in Japanese Patients with Helicobacter pylori Infection
TLDR
The prevalence of intestinal metaplasia of the gastric cardia and carditis in Japanese patients with H. pylori infection was similar to that of metapl Asia of antrum and lesser curvature of the stomach. Expand
Pathologic Features of Reflux and Helicobacter pylori-Associated Carditis: A Comparative Study
TLDR
Clinical and pathologic features of reflux carditis are distinct from H. pylori carditis and are characterized by less overall inflammation and fewer neutrophils and plasma cells, further supporting the hypothesis that multilayered epithelium may represent an early precursor in the development of columnar metaplasia in Barrett's esophagus. Expand
Bile reflux gastritis and intestinal metaplasia at the cardia
TLDR
Histological evidence of bile reflux into the stomach is associated with cardia IM, which could have an important bearing on carcinogenesis at this site. Expand
Inflammation and Intestinal Metaplasia of the Gastric Cardia: Helicobacter pylori, Gastroesophageal Reflux Disease, or Both
TLDR
The preponderance of data suggests that intestinal metaplasia of the cardia is associated with H. pylori infection as opposed to GERD, and preliminary data suggest a lower risk of progression to dysplasia and adenocarcinoma when compared to intestinal meta Plasmas of the distal esophagus. Expand
Helicobacter pylori eradication dramatically improves inflammation in the gastric cardia
TLDR
There is a dramatic improvement in the degree of inflammation and activity scores in the gastric cardia of patients with successful H. pylori eradication compared to those with persistent infection. Expand
Chronic inflammation at the gastroesophageal junction (carditis) appears to be a specific finding related to Helicobacter pylori infection and gastroesophageal reflux disease
TLDR
Two dissimilar types of chronic inflammation of the gastric cardia mucosa seem to occur, one existing in conjunction with chronic H. pylori gastritis and the other with normal stomach and erosive GERD. Expand
Inflammation of the gastric cardia in children with symptoms of acid peptic disease.
TLDR
In children with symptoms of acid peptic disease, inflammation of the gastric cardia does occur and is more severe when the cardiac zone is infected with H pylori than in its absence. Expand
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