Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer.

@article{Morris2011InflammationAI,
  title={Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer.},
  author={Patrick Glyn Morris and Clifford A. Hudis and Dilip Giri and Monica Morrow and Domenick J. Falcone and Xi Kathy Zhou and Baoheng Du and Edi Brogi and Carolyn B Crawford and Levy Kopelovich and Kotha Subbaramaiah and Andrew J. Dannenberg},
  journal={Cancer prevention research},
  year={2011},
  volume={4 7},
  pages={1021-9}
}
Obesity is a risk factor for the development of hormone receptor-positive breast cancer in postmenopausal women and has been associated with an increased risk of recurrence and reduced survival. In humans, obesity causes subclinical inflammation in visceral and subcutaneous adipose tissue, characterized by necrotic adipocytes surrounded by macrophages forming crown-like structures (CLS). Recently, we found increased numbers of CLS, activation of the NF-κB transcription factor, and elevated… CONTINUE READING
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