Inflammation and conjugated linoleic acid: mechanisms of action and implications for human health

  title={Inflammation and conjugated linoleic acid: mechanisms of action and implications for human health},
  author={Mar{\'i}a Angeles Zulet and Amelia Mart{\'i} and Ma Dolores Parra and J. Alfredo Mart{\'i}nez},
  journal={Journal of Physiology and Biochemistry},
Data from a number of studies and trials have shown that different conjugated linoleic acids (CLA’s) may produce beneficial effects on cancer, atherosclerosis, hypertension, diabetes and changes in body composition. Despite the increasing knowledge about CLA’s implications on health, the mechanism of action of these fatty acids is not completely understood. Moreover, human studies indicate that some of these beneficial effects are considerably less evident than anticipated from mice studies… 

Efecto del ácido linoleico conjugado (CLA) sobre el perfil lipídico en humanos

The aim of this review was to gather up-to-date available data about the effects of CLA on human lipid profile and found that studies with a duration of two weeks, carried out using a mix of equal amounts of the two main CLA isomers, seem to offer the most beneficial results.

Effect of conjugated linoleic acid on blood inflammatory markers: a systematic review and meta-analysis on randomized controlled trials

This meta-analysis showed that CLA supplementation may increase inflammatory markers (CRP and TNF-α) and there are concerns about using CLA supplementation as an anti-obesity agent among the obese population for at least a short duration.

Isomer specificity of conjugated linoleic acid (CLA): 9E,11E-CLA

Various effects of CLAs, especially anti-inflammatory and anti-atherogenic effects, will be discussed with focusing on the isomer-specific effects and potential mechanism of action of CLA.

Trans-11 vaccenic acid dietary supplementation induces hypolipidemic effects in JCR:LA-cp rats.

In conclusion, short-term dietary supplementation of 1.5% VA did not result in any detrimental metabolic effects in JCR:LA-cp rats, and dietary VA had substantial hypo-triglyceridemic effects, suggesting a new bioactivity of this fatty acid that is typically found in ruminant-derived food products.

A randomised, double blind, crossover study of the effects of CLA isomers on inflammation, body composition, metabolic profiles and vascular function in subjects with the metabolic syndrome

Dietary supplementation with CLA seems to produce a number of vascular benefits which are noted to be independent of its metabolic effects and mediated possibly by attenuating inflammation through changes in circulatory sRAGE.

Fatty acids, inflammation, and asthma.

Effects of pterostilbene in brown adipose tissue from obese rats

It is shown for the first time that pterostilbene increases thermogenic and oxidative capacity of brown adipose tissue in obese rats.

Effects of pterostilbene in brown adipose tissue from obese rats

For the first time, pterostilbene increases thermogenic and oxidative capacity of brown adipose tissue in obese rats and whether these effects effectively contribute to the antiobesity properties of these compound needs further research.



Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action.

  • M. Belury
  • Medicine
    Annual review of nutrition
  • 2002
Health benefits, metabolism, and potential mechanisms of action of CLA are focused on and the implications regarding dietary CLA for human health are postulated.

Colonic anti-inflammatory mechanisms of conjugated linoleic acid.

Evidence supporting both mechanistic theories of CLA acting through eicosanoid synthesis and PPAR activity is available, and the further understanding of the anti-inflammatory mechanisms of action of CLA may yield novel nutritional therapies for enteric inflammation.

Mechanisms of Action of Conjugated Linoleic Acid: Evidence and Speculation

It is emphasized the importance of considering the effects, both individually and combined, of the two CLA isomers that have been shown to exhibit biological activity and which appear to exert their effects via different biochemical mechanisms.

Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature.

  • A. Terpstra
  • Biology
    The American journal of clinical nutrition
  • 2004
The results of the studies in humans indicate that the effect of CLA on body fat is considerably less than that anticipated from mice studies and that CLA has no major effect on plasma lipids.

Conjugated linoleic acid in humans: regulation of adiposity and insulin sensitivity.

This review presents the current understanding of potential isomer-specific mechanisms by which CLA reduces human adiposity and insulin sensitivity and demonstrates that trans-10, cis-12 CLA prevents triglyceride (TG) accumulation in primary cultures of differentiating human preadipocytes.

Conjugated Linoleic Acid and Disease Prevention: A Review of Current Knowledge

  • H. Macdonald
  • Biology
    Journal of the American College of Nutrition
  • 2000
In vitro results suggest that CLA is cytotoxic to MCF-7 cells and it inhibits the proliferation of human malignant melanoma and colorectal cancer cells, and it is now thought that CLA itself may not have anti-oxidant capabilities but may produce substances which protect cells from the detrimental effects of peroxides.

Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid.

Investigation of the anti-inflammatory actions and molecular mechanisms underlying the regulation of colonic health by CLA hypothesized that colonic inflammation can be ameliorated by dietary CLA supplementation, and found that CLA fed preventively before the onset of enteric disease attenuated inflammatory lesion development and growth failure.

Conjugated linoleic acid: implications for human health.

This review will examine the literature on CLA and discuss the animal research on which the above claims are made and an evaluation of the potential uses of CLA for human health and disease.

Supplementation With Conjugated Linoleic Acid Causes Isomer-Dependent Oxidative Stress and Elevated C-Reactive Protein: A Potential Link to Fatty Acid-Induced Insulin Resistance

The oxidative stress seems closely related to induced insulin resistance, suggesting a link between the fatty acid-induced lipid peroxidation seen in the present study and insulin resistance.