Inflammation and conjugated linoleic acid: mechanisms of action and implications for human health

@article{Zulet2009InflammationAC,
  title={Inflammation and conjugated linoleic acid: mechanisms of action and implications for human health},
  author={M. Zulet and A. Mart{\'i} and M. D. Parra and J. Mart{\'i}nez},
  journal={Journal of Physiology and Biochemistry},
  year={2009},
  volume={61},
  pages={483-494}
}
Data from a number of studies and trials have shown that different conjugated linoleic acids (CLA’s) may produce beneficial effects on cancer, atherosclerosis, hypertension, diabetes and changes in body composition. Despite the increasing knowledge about CLA’s implications on health, the mechanism of action of these fatty acids is not completely understood. Moreover, human studies indicate that some of these beneficial effects are considerably less evident than anticipated from mice studies… Expand
View on Springer
ncbi.nlm.nih.gov
60 Citations
Highly Influential Citations
2
Background Citations
19
Methods Citations
1
Results Citations
1

60 Citations

Citation Type

Citation Type

Efecto del ácido linoleico conjugado (CLA) sobre el perfil lipídico en humanos
TLDR
The aim of this review was to gather up-to-date available data about the effects of CLA on human lipid profile and found that studies with a duration of two weeks, carried out using a mix of equal amounts of the two main CLA isomers, seem to offer the most beneficial results. Expand
Efecto del ácido linoleico conjugado (CLA) sobre el perfil lipídico en humanos
SUMMARY. Effect of conjugated linoleic acid (CLA) on human lipid profile. The term conjugated linoleic acid (CLA) concerns a group of isomers of linoleic acid, which are characterized by having… Expand
Effect of conjugated linoleic acid on blood inflammatory markers: a systematic review and meta-analysis on randomized controlled trials
TLDR
This meta-analysis showed that CLA supplementation may increase inflammatory markers (CRP and TNF-α) and there are concerns about using CLA supplementation as an anti-obesity agent among the obese population for at least a short duration. Expand
Isomer specificity of conjugated linoleic acid (CLA): 9E,11E-CLA
TLDR
Various effects of CLAs, especially anti-inflammatory and anti-atherogenic effects, will be discussed with focusing on the isomer-specific effects and potential mechanism of action of CLA. Expand
The Effects of Simultaneous Administration of Dietary Conjugated Linoleic Acid and Telmisartan on Cardiovascular Risks in Rats
TLDR
It is suggested that a combination of CLA with telmisartan may modify several risk factors of cardiovascular disease commonly seen in metabolic syndrome and may be a safe and cost-effective strategy in a number of high-risk subjects. Expand
Trans-11 vaccenic acid dietary supplementation induces hypolipidemic effects in JCR:LA-cp rats.
TLDR
In conclusion, short-term dietary supplementation of 1.5% VA did not result in any detrimental metabolic effects in JCR:LA-cp rats, and dietary VA had substantial hypo-triglyceridemic effects, suggesting a new bioactivity of this fatty acid that is typically found in ruminant-derived food products. Expand
Should the pharmacological actions of dietary fatty acids in cardiometabolic disorders be classified based on biological or chemical function?
TLDR
The effects of different dietary fatty acids on the cardiometabolic risk factors are examined, a revised classification based on current evidence of biological activity, rather than chemical structure is proposed and five classes of fatty acids are classified into five classes as neutral. Expand
A randomised, double blind, crossover study of the effects of CLA isomers on inflammation, body composition, metabolic profiles and vascular function in subjects with the metabolic syndrome
TLDR
Dietary supplementation with CLA seems to produce a number of vascular benefits which are noted to be independent of its metabolic effects and mediated possibly by attenuating inflammation through changes in circulatory sRAGE. Expand
Fatty acids, inflammation, and asthma.
TLDR
The role of fatty acid inflammatory and resolving mediators is focused on and the clinical and epidemiologic data on how diet and obesity alter fatty acid profiles that can contribute to asthma are summarized. Expand
Effects of pterostilbene in brown adipose tissue from obese rats
TLDR
It is shown for the first time that pterostilbene increases thermogenic and oxidative capacity of brown adipose tissue in obese rats. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 83 REFERENCES
Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action.
  • M. Belury
  • Biology, Medicine
  • Annual review of nutrition
  • 2002
TLDR
Health benefits, metabolism, and potential mechanisms of action of CLA are focused on and the implications regarding dietary CLA for human health are postulated. Expand
Colonic anti-inflammatory mechanisms of conjugated linoleic acid.
TLDR
Evidence supporting both mechanistic theories of CLA acting through eicosanoid synthesis and PPAR activity is available, and the further understanding of the anti-inflammatory mechanisms of action of CLA may yield novel nutritional therapies for enteric inflammation. Expand
Conjugated linoleic acid and obesity control: efficacy and mechanisms
TLDR
CLA reduces weight gain and fat deposition in rodents, while produces less significant and inconsistent effects on body weight and composition in pigs and humans. Expand
Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPARγ-dependent mechanism
TLDR
Results suggest that CLA has anti-inflammatory properties that are mediated, at least in part, by the nuclear hormone receptor PPARg. Expand
Mechanisms of Action of Conjugated Linoleic Acid: Evidence and Speculation
TLDR
It is emphasized the importance of considering the effects, both individually and combined, of the two CLA isomers that have been shown to exhibit biological activity and which appear to exert their effects via different biochemical mechanisms. Expand
Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature.
  • A. Terpstra
  • Medicine, Chemistry
  • The American journal of clinical nutrition
  • 2004
TLDR
The results of the studies in humans indicate that the effect of CLA on body fat is considerably less than that anticipated from mice studies and that CLA has no major effect on plasma lipids. Expand
Conjugated linoleic acid in humans: regulation of adiposity and insulin sensitivity.
TLDR
This review presents the current understanding of potential isomer-specific mechanisms by which CLA reduces human adiposity and insulin sensitivity and demonstrates that trans-10, cis-12 CLA prevents triglyceride (TG) accumulation in primary cultures of differentiating human preadipocytes. Expand
Conjugated Linoleic Acid and Disease Prevention: A Review of Current Knowledge
  • H. Macdonald
  • Biology, Medicine
  • Journal of the American College of Nutrition
  • 2000
TLDR
In vitro results suggest that CLA is cytotoxic to MCF-7 cells and it inhibits the proliferation of human malignant melanoma and colorectal cancer cells, and it is now thought that CLA itself may not have anti-oxidant capabilities but may produce substances which protect cells from the detrimental effects of peroxides. Expand
Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid.
TLDR
Investigation of the anti-inflammatory actions and molecular mechanisms underlying the regulation of colonic health by CLA hypothesized that colonic inflammation can be ameliorated by dietary CLA supplementation, and found that CLA fed preventively before the onset of enteric disease attenuated inflammatory lesion development and growth failure. Expand
Conjugated linoleic acid: implications for human health.
TLDR
This review will examine the literature on CLA and discuss the animal research on which the above claims are made and an evaluation of the potential uses of CLA for human health and disease. Expand
...
1
2
3
4
5
...