Inflammation and ageing

  title={Inflammation and ageing},
  author={Prof. Dr. med. Ursula M{\"u}ller-Werdan},
  journal={Zeitschrift f{\"u}r Gerontologie und Geriatrie},
An enhanced inflammatory state – i.e. “inflammatory/pathogen burden” – in the elderly on the one hand results from physiological immunosenescence and on the other hand is modified by the individual immune history: the latter is determined by sequential infectious/pathogenic events (“multiple hits”). Immunosenescence may prompt ageing of other organs. Cardiac ageing can be assessed by analysing heart rate variability. We present our hypothesis that the increasing “inflammatory/pathogen burden… CONTINUE READING
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