Inflammation and adipose tissue macrophages in lipodystrophic mice.

@article{Herrero2010InflammationAA,
  title={Inflammation and adipose tissue macrophages in lipodystrophic mice.},
  author={Laura Nunez Herrero and Hagit Shapiro and Ali Nayer and Jongsoon Lee and Steven E. Shoelson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 1},
  pages={240-5}
}
Lipodystrophy and obesity are opposites in terms of a deficiency versus excess of adipose tissue mass, yet these conditions are accompanied by similar metabolic consequences, including insulin resistance, dyslipidemia, hepatic steatosis, and increased risk for diabetes and atherosclerosis. Hepatic and myocellular steatosis likely contribute to metabolic dysregulation in both states. Inflammation and macrophage infiltration into adipose tissue also appear to participate in the pathogenesis of… CONTINUE READING

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