Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes.

  title={Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes.},
  author={John C Pickup},
  journal={Diabetes care},
  volume={27 3},
There is increasing evidence that an ongoing cytokine-induced acute-phase response (sometimes called low-grade inflammation, but part of a widespread activation of the innate immune system) is closely involved in the pathogenesis of type 2 diabetes and associated complications such as dyslipidemia and atherosclerosis. Elevated circulating inflammatory markers such as C-reactive protein and interleukin-6 predict the development of type 2 diabetes, and several drugs with anti-inflammatory… CONTINUE READING
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