Inflammation and Spinal Cord Injury: Infiltrating Leukocytes as Determinants of Injury and Repair Processes.

@article{Trivedi2006InflammationAS,
  title={Inflammation and Spinal Cord Injury: Infiltrating Leukocytes as Determinants of Injury and Repair Processes.},
  author={Alpa A. Trivedi and Andrea D Olivas and L J Noble-Haeusslein},
  journal={Clinical neuroscience research},
  year={2006},
  volume={6 5},
  pages={283-292}
}
The immune response that accompanies spinal cord injury contributes to both injury and reparative processes. It is this duality that is the focus of this review. Here we consider the complex cellular and molecular immune responses that lead to the infiltration of leukocytes and glial activation, promote oxidative stress and tissue damage, influence wound healing, and subsequently modulate locomotor recovery. Immunomodulatory strategies to improve outcomes are gaining momentum as ongoing… CONTINUE READING