Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells.

@article{Urrutia2013InflammationAT,
  title={Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells.},
  author={Pamela J. Urrutia and Pabla Aguirre and Andr{\'e}s L Esparza and Victoria Tapia and Natalia Mena and Miguel O Arredondo and Christian Gonz{\'a}lez-Billault and Marco T. Nu{\~n}ez},
  journal={Journal of neurochemistry},
  year={2013},
  volume={126 4},
  pages={541-9}
}
Inflammation and iron accumulation are present in a variety of neurodegenerative diseases that include Alzheimer's disease and Parkinson's disease. The study of the putative association between inflammation and iron accumulation in central nervous system cells is relevant to understand the contribution of these processes to the progression of neuronal death. In this study, we analyzed the effects of the inflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) and of… CONTINUE READING

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