Inflammation alters cation chloride cotransporter expression in sensory neurons

  title={Inflammation alters cation chloride cotransporter expression in sensory neurons},
  author={Begonia M Morales-Aza and Naomi L. Chillingworth and John A. Payne and Lucy F Donaldson},
  journal={Neurobiology of Disease},
Cation chloride cotransporters have been proposed to play a role in the modulation of neuronal responses to gamma-aminobutyric acid (GABA). In conditions of neuronal damage, where neuronal excitability is increased, the expression of the KCC2 transporter is decreased. This is also seen in spinal cord in models of neuropathic pain. We have investigated the expression of the Na-K-Cl, and K-Cl cotransporters NKCC1 and KCC2, in dorsal root ganglion (DRG) and spinal sensory neurons during arthritis… CONTINUE READING


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