Inflammation-Mediated Regulation of MicroRNA Expression in Transplanted Pancreatic Islets

  title={Inflammation-Mediated Regulation of MicroRNA Expression in Transplanted Pancreatic Islets},
  author={Valia Bravo-Ega{\~n}a and Samuel Rosero and D. Klein and Zhijie Jiang and Nancy Vargas and Nicholas F. Tsinoremas and Marco Doni and Michele Podetta and Camillo Ricordi and Ruth Damaris Molano and Antonello Pileggi and Ricardo Luis Pastori},
  booktitle={Journal of transplantation},
Nonspecific inflammation in the transplant microenvironment results in β-cell dysfunction and death influencing negatively graft outcome. MicroRNA (miRNA) expression and gene target regulation in transplanted islets are not yet well characterized. We evaluated the impact of inflammation on miRNA expression in transplanted rat islets. Islets exposed in vitro to proinflammatory cytokines and explanted syngeneic islet grafts were evaluated by miRNA arrays. A subset of 26 islet miRNAs was affected… CONTINUE READING
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