Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction

@article{Liu2016InflammationIG,
  title={Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction},
  author={Junli Liu and Dorina Ibi and Kōji Taniguchi and Jaemin Lee and Hilde Herrema and Bedia Akosman and Patrick Mucka and Mario Andres Salazar Hernandez and Muhemmet Fatih Uyar and Sang Won Park and M. Gilljam Karin and Umut Ozcan},
  journal={Cell},
  year={2016},
  volume={167},
  pages={1052-1066.e18}
}
It is widely believed that inflammation associated with obesity has an important role in the development of type 2 diabetes. IκB kinase beta (IKKβ) is a crucial kinase that responds to inflammatory stimuli such as tumor necrosis factor α (TNF-α) by initiating a variety of intracellular signaling cascades and is considered to be a key element in the inflammation-mediated development of insulin resistance. We show here, contrary to expectation, that IKKβ-mediated inflammation is a positive… CONTINUE READING
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